In a high-performance system, hitting disk storage is an unpleasant place to be -- and, for the most part, you actually don't have to. ORMs and SQL databases might seem like a necessary evil, but do we actually need them?
In this talk we'll take a look at CQRS and event sourcing as a way to create systems with extremely high throughput and low latency.
There is a version of Your domain model is too big for RAM (and other fallacies) that I presented at DDD Brisbane 2013 on YouTube.
You can always have a look at my talk videos or blog posts for inspiration - or just point me at your audience and let's see what happens :)